Metabolic syndrome is a group of metabolic disorders that increase the risk of cardiovascular diseases, type 2 diabetes, and other health issues. It is closely linked to lifestyle factors and is becoming a global health concern. Treatment primarily involves lifestyle changes, such as a healthy diet, exercise, and weight loss. However, pharmacological interventions are often needed to manage conditions like hypertension, hyperglycemia, and dyslipidemia. Due to its rising prevalence, metabolic syndrome emphasizes the need for preventive strategies and early intervention to reduce long-term health risks.
Grants
The following projects aim to determine the therapeutic effects of various TSPO protein ligands in metabolic disorders. These studies are conducted using zebrafish model organism, which provides a valuable system for investigating metabolic processes and potential pharmacological interventions.
Zebrafish serve as an excellent model due to their genetic similarity to humans, transparent embryos that allow for real-time observation of physiological changes, and rapid development, which facilitates efficient screening of therapeutic compounds. By analyzing the impact of different TSPO ligands on metabolic regulation, these projects seek to uncover novel therapeutic strategies that could contribute to the treatment of metabolic disorders.
Studies on the post-receptor mechanisms of TSPO in search of a novel therapeutic target of metabolic syndrome. Grant no. 2022/45/N/NZ7/02076. National Science Center, Poland. PI: Łukasz Kurach
Evaluation of the multidirectional action of selected TSPO protein ligands in glycemia disorders in Danio rerio. Grant for young scientists, grant no. PBmb212, Medical University of Lublin, Poland. PI: Łukasz Kurach
